enhancer3D: 3D chromatin structures and enhancer-promoter distance profiles for archaic and modern human genomes

Spatial interactions between enhancers and promoters (E-P) are fundamental to gene regulation, yet understanding their evolution, particularly in the context of human divergence and uniqueness, remains a significant challenge. To address this, we present enhancer3D, which is, to our knowledge, the first publicly accessible database of 3D chromatin model ensembles for archaic (Neanderthal and Denisovan) and modern human genomes. The resource enables comparative analysis of E-P spatial distance...