PBMCpedia: a harmonized PBMC scRNA-seq database with unified mapping and enhanced celltype annotation

Single-cell transcriptomic studies of peripheral blood mononuclear cells (PBMCs) offer valuable insights into immune states across diverse biological conditions, yet cross-study integration remains difficult due to divergent preprocessing and annotations. PBMCpedia addresses this by uniformly reprocessing 519 samples (over 4.3 million cells) from 24 publicly available single-cell RNA sequencing studies using a standardized pipeline with consistent quality control and hierarchical cell type...