SIGNOR 4.0: the 2025 update with focus on phosphorylation data

The SIGnaling Network Open Resource (SIGNOR 4.0, https://signor.uniroma2.it) is a database of manually curated causal interactions between biological entities. These signaling events are annotated along with their effect-denoting the activation or inactivation of a target entity-and mechanism through which it is mediated, such as phosphorylation, binding, or transcriptional regulation. The data is freely accessible and can be explored as customizable signaling networks, allowing users to adapt...