Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents
(database[TitleAbstract]) AND (Nucleic acids research[Journal]) 2022-02-01
Summary:
Drug discovery relies on the knowledge of not only drugs and targets, but also the comparative agents and targets. These include poor binders and non-binders for developing discovery tools, prodrugs for improved therapeutics, co-targets of therapeutic targets for multi-target strategies and off-target investigations, and the collective structure-activity and drug-likeness landscapes of enhanced drug feature. However, such valuable data are inadequately covered by the available databases. In this...