A longitudinal analysis of function annotations of the human proteome reveals consistently high biases

The resources required to study gene function are limited, especially when considering the number of genes in the human genome and the complexity of their function. Therefore, genes are prioritized for experimental studies based on many different considerations, including, but not limited to, perceived biomedical importance, such as disease-associated genes, or the understanding of biological processes, such as cell signalling pathways. At the same time, most genes are not studied or are...