p53motifDB: integration of genomic information and tumour suppressor p53 binding motifs

The tumour suppressor gene TP53 encodes the DNA binding transcription factor p53 and is one of the most mutated genes in human cancer. Tumour suppressor activity requires binding of p53 to its DNA response elements and subsequent transcriptional activation of a diverse set of target genes. Despite decades of close study, the logic underlying p53 interactions with its numerous potential genomic binding sites and target genes is not yet fully understood. Here, we present a database of DNA and...