H-SPAR DB: human spaceflight platform for analysis and research-an integrative omics database for space health

Database (Oxford). 2026 Jan 15;2026:baaf083. doi: 10.1093/database/baaf083.

ABSTRACT

H-SPAR DB is a comprehensive database designed to support space health research by providing a unified platform for data integration, analysis, and interpretation. The database simplifies the complex workflows associated with spaceflight-related biology studies by combining curated molecular lists, transcriptomic datasets from NASA's GeneLab, and user-uploaded data into a streamlined, user-friendly interface. H-SPAR DB enables researchers to perform differential expression analysis, set operations, and association analyses while also generating integrative knowledge graphs around a space-related biological theme. The platform reduces the time required for data gathering and processing by offering a single platform for data exploration, analysis, and visualization. By integrating interactive visualizations and data tables, H-SPAR DB facilitates the interpretation of results, ultimately enhancing the efficiency of space biology research and fostering discoveries that address human health challenges in space. Researchers can access H-SPAR DB freely at https://bioinformatics.cing.ac.cy/H-SPARDB/ without login or other requirements.

PMID:41537191 | PMC:PMC12805116 | DOI:10.1093/database/baaf083