Constructing High-Fidelity Phenotype Knowledge Graphs for Infectious Diseases With a Fine-Grained Semantic Information Model: Development and Usability Study

CONCLUSIONS: PhenoSSU is an effective information model for the precise representation of phenotype knowledge for clinical guidelines, and machine learning can be used to improve the efficiency of constructing PhenoSSU-based knowledge graphs. Our work will potentially shift the focus of medical knowledge engineering from a coarse-grained level to a more fine-grained level.